Description of the project

MEMOVE is a transdisciplinary proposal that aims at developing new mathematical models, numerical tools as well as new experimental protocols to provide a complete understanding of the electropermeabilization from the cell to the tissue scale. The consortium is composed of four partners with complementary skills:
  • the Inria research team MC2, which is the leading partner of MEMOVE,
  • the bioengineering laboratory Ampère at Lyon,
  • the Vectorology and Anticancerous Therapeutics lab at the Institut Gustave Roussy (VAT lab) at Villejuif.
The electroporation modeling will be developed thanks to two-way links between the numerical simulations and the experiments: the experimental results providing preliminary results to the modeling, which then will highlight a priori the main phenomena of the experiments. The fitting of the model based on PDEs is the key point of the project. This will be performed by a data assimilation procedure well known by the INRIA team MC2.
At the cell scale, it is proposed to develop new electrical cell PDEs models that describe simultaneously the electropermeabilization by micropulses, and the electrophysiological changes of the cell during the process (cell swelling, ions fluxes in the cell...). Moreover a theoretical asymptotic analysis will be performed to study the electropermeabilization of closely touching cells, while homogenization of single cell models will help in the understanding of the electroporation of cell suspension solution. From the experimental point of view, new device manufacturing to simultaneously electroporate vesicles and quantify this electroporation will be performed. These experiments will highlight the specificity of cell electroporation, when compared to the simplest experimental cell model that is liposome.
At the tissue scale, MEMOVE aims at providing a non-linear tissue conductivity modeling, with parameters that will be fitted with the experiments on potatoes, and rat liver, through data assimilation techniques based on proper orthogonal decomposition developed by MC2. Here again, both numerical and experimental influences of the pulse properties on the tissue electroporation will be investigated.
The final goal of the project, once these multiscale models will be derived, is to provide numerical tools that ensure the optimal pulse delivery for a given realistic geometry of tissue, in order to propose a code that could be useful to the physician applying electrochemotherapy as cancer treatment. The full human body meshing developed by Ampère will be useful to perform the robust optimization to ensure the best pulse delivery that will be addressed by Ampère, MC2 and LMV. The results will be proposed to the VAT lab to test the procedure on the electroporation on small animals and to evaluate the consistence of the optimization.

Coordinators of the consortium

Four local managers coordinate the consortium MEMOVE:

  • Dr Clair Poignard, P.I. of the consortium, researcher (PhD, HdR) at Inria Bordeaux.
  • Prof. François Buret, Professor (PhD, HdR) at Ecole Centrale Lyon.
  • Dr Lluis M. Mir, senior researcher (PhD, HdR) at the Vectorology and Anticancerous Therapeutics lab of CNRS, Institut Gustave Roussy and Paris XI.

News and Events

  • 15th-16th Dec 2014:
    Workshop on electroporation and Biophysical therapies
  • 6th March 2014:
    Meeting at Lyon
  • 2nd-3rd Sept 2014:
    Meeting at Villejuif
  • 6th March 2014:
    Meeting at Lyon
  • 7-8th October 2013:
    Meeting at Paris (CR)
  • 19-20th february 2013:
    Meeting at Bordeaux (CR)
  • 14-15th November 2012:
    Meeting at Lyon (CR)
  • 13th March 2012:
    Meeting at Paris (CR)
  • January 2012:
    Kick-off meeting at Bordeaux
  • Links

  • ARC C3MB (2009-2010)
  • ANR INTCELL (2011-2013)

  • Project Coordinator

    Clair POIGNARD (website)
    EPI MC2
    INRIA Bordeaux-Sud Ouest
    351 Cours de la Libération
    F-33405 Talence, France