Members

EPI MC2 VAT lab Ampère
Coordinator C. Poignard L.M. Mir F. Buret
Participants T. Colin F. André M. Frénéa
O. Kavian I. Leray N. Haddour
O. Saut T. Ragot L. Krähenbühl
L. Weynans R. Perrussel
R. Scorretti
D. Voyer
Postdoc & PhD Students M. Leguèbe (2011-2014) M. Breton
M. Deville (Sep. 2014-...) A. Silve

Description of the partners

EPI MC2

The INRIA Research Project-Team MC2 have successfully developed mathematical models and numerical techniques for tumor growth for several years. These models are based on partial differential equations. Members have worked with PDEs in various domains of applications for decade. They have obtained numerous results concerning the mathematical behavior of solutions to these equations and have developed numerical schemes adequate to compute numerically their solutions. This expertise (in particular in the fluid dynamics, electromagnetism and optics themes) is now applied to biological problems arising from cancer. MC2 has obtained realistic three-dimensional computations of a cancer growth or of the process of angiogenesis. It has been extended to image-based simulation using the POD techniques. The research project of MC2 is to keep on developing models adapted for specific types of cancer (brain tumors, colorectal cancers) with a focusing on local treatment such as electrochemotherapy. Aside from developing models and ensuring they behave “correctly” from a mathematical point of view, an extra care has to be taken on the numerical methods used. Adequate numerical schemes are needed. The team will benefit from the works of the INRIA project team MC2 on complex fluids (our latest model treats cancer cells as a viscoelastic fluid for instance). The MC2 team has also started parallelizing the various algorithms to shorten computation times of the simulations (which can be particularly expensive in 3D). From a description at the cellular level, the team aims at obtaining accurate models that will be fitted by the experiments using the POD techniques previously used for tumor growth modeling. These models will then be eventually coupled with the models for cancer growth developed by MC2 in another research project in order to evaluate the influence of electrochemotherapy on the tumor growth for instance. Prof. Kavian, from UVSQ will be associated to the Inria partner. He has a strong expertise on mathematical modeling and on large-scale simulations of complex phenomena. He will work on the modeling at the microscopic scale for electroporation models, and on the homogenization of the cell models.

Laboratoire Ampère

Ampère is a multidisciplinary laboratory, which is concerned by three scientific fields: Automatic, Electrical Engineering (Electromagnetism) and Environmental Microbiology. Mechatronic Engineering and Bioengineering are its two scientific objectives. It has developed a research activity in the domain of the interaction between living matter and electromagnetic field. The overall aim of our work in this domain is to understand what happens at the cell level when electromagnetic fields are applied at the macroscopic scale (organs, entire body...). The long-term guideline of our work in this domain is to build a link between the cell and the tissue concerning electromagnetic phenomena: electromagnetic properties, field distribution... At the present time, the “Bioélectromagnétisme et Microsystèmes” group2 is working mainly at the cell scale by developing: 1. numerical techniques to model the cell on an electromagnetic point of view. In particular we have developed models which permit to compute the transmembrane voltage which is the first approach of electropermeabilization 2. microsystems, which permit to manipulate, characterize and modify single cells (eukaryote and prokaryote). For example we are developing a microsystem, which permit to perform an electrofusion between two cells (Contrat Region Rhone-Alpes:- cluster Pnano). Ampère takes advantage of a high skill in field computation, which has been developed during the last thirty years and the development of new experimental facilities in the domain of microbiology, that permits to manipulate biological cells. One of the last ANR project (ANR CES – projet Emergent) is a good illustration of the possibilities we have in cell manipulation and biological analysis. This project deals with the manipulation of cells which have internalized DNA labeled by magnetic nanoparticules is achieved.

VAT lab

The team of the CNRS “Vectorology and Anticancer Therapies”, UMR 8203 at the Institut Gustave Roussy (IGR) is interested in the study of the interactions between electric fields and cells in in vitro and in vivo experiments. The team is one of the pioneers of the therapeutic use of electroporation and its members have a deep knowledge of the biological phenomena involved in electroporation. Therefore they will bring invaluable help to develop accurate and realistic mathematical models. The partner will provide the project with experimental data ranging from electroporation at the cellular level to the macroscopic level with results on electroporation at the tissue level in several tissues. These tissues will be isotropic (potato tuber, mice liver) or anisotropic (mice muscles), animal (liver, muscle) or vegetal (potato), that have been chosen for their easy manipulation (e.g. potato), for their geometrical properties (isotropic versus anisotropic tissues) or biological properties (presence or not of gap- junctions electrically linking the cells). The comparisons that will be performed using these different tissues will bring important information to build or to validate the mathematical models.

News and Events

  • 15th-16th Dec 2014:
    Workshop on electroporation and Biophysical therapies
  • 2nd-3rd Sept 2014:
    Meeting at Villejuif
  • 6th March 2014:
    Meeting at Lyon
  • 7-8th October 2013:
    Meeting at Paris (CR)
  • 19-20th february 2013:
    Meeting at Bordeaux (CR)
  • 14-15th November 2012:
    Meeting at Lyon (CR)
  • 13th March 2012:
    Meeting at Paris (CR)
  • January 2012:
    Kick-off meeting at Bordeaux
  • Links

  • ARC C3MB (2009-2010)
  • ANR INTCELL (2011-2013)


  • Project Coordinator

    Clair POIGNARD (website)
    EPI MC2
    INRIA Bordeaux-Sud Ouest
    351 Cours de la Libération
    F-33405 Talence, France
    webmaster