Research reports and on-line preprints

  • F. Buret, N. Faure, L. Nicolas, R. Perrussel and C. Poignard.
    "Numerical studies on the effect of electric pulses on an egg-shaped cell with a spherical nucleus".
    Research report INRIA RR-7270. Submitted.
  • Scientific Publications

  • A. Silve, I. Leray, C. Poignard, L. M. Mir.
    " Impact of external medium conductivity on cell membrane electropermeabilization by microsecond and nanosecond electric pulses."
    Published on-line in Scientific Reports 6.
  • A. Silve, I. Leray, M. Leguèbe, C. Poignard, L. M. Mir.
    " Cell membranes permeabilisation by 12 ns electric pulses: not a purely dielectric but a charge dependant phenomenon."
    Published in Bioelectrochemistry, Vol. 106, Part B (2015)
  • M. Leguèbe, C. Poignard, L. Weynans.
    "A second-order Cartesian method for the simulation of electropermeabilization cell models". Published in Jnl. Comp. Phys. Vol. 292 (2015).
  • M. Breton, F. Buret, L. Krähenbühl, M. Leguèbe, L.M. Mir, R. Perrussel, C. Poignard, R. Scorretti, D. Voyer.
    "Nonlinear steady-state electrical current modeling for the electropermeabilization of biological tissue". Published in IEEE Trans. on Mag. Vol. 51 (2015).
  • F. Salomone, M. Breton, I. Leray, F. Cardarelli, C. Boccardi, D. Bonhenry, M. Tarek, L. M. Mir and F. Beltram. "High-yield non-toxic gene transfer through conjugation of CM18-Tat11 chimeric peptide with nanosecond electric pulses". Molecular Pharmaceutics, 11, 2466-2474, 2014
  • A. Silve, A. Guimerà Brunet, B. Al-Sakere, A. Ivorra and L.M. Mir. "Comparison of the effects of the repetition rate between microsecond and nanosecond pulses: Electropermeabilisation-induced electro-desensitization?" Biophysical Biochemical Acta – Biomembranes, 1840, 2139-2151, (2014).
  • M. Leguèbe, A. Silve, L.M. Mir, C. Poignard.
    "Conducting and permeable states of cell membrane submitted to high voltage pulses. Mathematical and numerical studies based on experiments". published on-line: Jrnl. Theoretical Biology (2014).
  • M. Duruflé, V. Péron, C. Poignard. Thin Layer Models For Electromagnetism. CiCP. Vol. 16, Issue 01, (2014).
  • O. Kavian, M. Leguèbe, C. Poignard, L. Weynans.
    "Classical electropermeabilization modelling at the cell scale". Jrnl of Math. Bio. Vol 68, Issue 1-2, (2014).
  • R. Perrussel, C. Poignard: "Asymptotic Expansion of Steady-State Potential in a High Contrast Medium with a Thin Resistive Layer" Applied Mathematics and Computation, Vol. 221, 2013.
  • M. de Menorval, L.M. Mir, M. L. Fernandez, R. Reigada.
    "Effects of Dimethyl Sulfoxide in Cholesterol-Containing Lipid Membranes: A Comparative Study of Experiments In Silico and with Cells". PlosOne. Vol 7, Issue 7, (2012).
  • M. Breton, L. Delemotte, A. Silve, L.M. Mir, M. Tarek. "Transport of siRNA through Lipid Membranes Driven by Nanosecond Electric Pulses: An Experimental and Computational Study". J. Am. Chem. Soc., Vol. 134 (2012)
  • Theses within the consortium

  • M. Deville. (PhD Thesis started in sept. 2014) Modeélisation de l'électroporation et de la transfection de geènes a l'échelle du tissu. Aspects théoriques et numeériques. Advisors: C. Poignard (Inria Bordeaux) and R. Natalini (CNR Rome).
  • M. Leguèbe. (PhD Thesis defended in sept. 2014) Modélisation de l'électroperméabilisation à l'échelle cellulaire. Advisors: T. Colin and C. Poignard.
  • C. Poignard. (HdR Thesis defended in sept. 2014) A few advances in biological modeling and asymptotic analysis. Contribution en modélisation de phénomènes biologiques et en analyse asymptotique.
  • Popular Science Publications

  • C. Poignard, A. Silve. Différence de potentiel induite par un champ électrique sur la membrane d'une cellule biologique . La Revue 3EI, N°75, Jan 2014.
  • C. Y. Calvet, L.M. Mir. Applications Biomédicales des impulsions électriques milli- et microsecondes. La Revue 3EI, N°75, Jan 2014.
  • M-A. de Menorval, A. Silve, L.M. Mir. Les impulsions éelectriques ultracourtes, de quelques nanosecondes: un outil pour manipuler l'intérieur des cellules. La Revue 3EI, N°75, Jan 2014.
  • Keynote Lectures in International Conferences

  • C. Poignard (keynote lecture): "Mathematics for Medical Applications: how medical imaging can help in mathematical modeling?" at Practice of Mathematical Medicine , Autumn school by Japanese and French mathematicians, Osaka, Japan, Nov 2014.
  • L. M. Mir (invited speaker): "A succesfull story: Electrochemotherapy, from a concept to a treatment, and the leverage by European funds" Bilat_UKRAINIA: Summer School on European RTDI policies, instruments and participation possibilities, September 15, 2014 – Kiev, UKRAINIA
  • L. M. Mir (invited speaker) Interactions of electric fields with living organisms - Part I-II-III at MONABIPHOT International Summer School, Anglet, France, June 2014.
  • L. M. Mir (invited speaker): "Electrochemotherapy: a developing new method for cancer treatment" MIPRO 2014 – COST action TD 1104 Special session, Opatija, Croatia, May 2014.
  • L. M. Mir (invited speaker): "Basic mechanisms of electroporation" at International School of Bioelectromagnetism « Alessandro Chiabrera » 7th Course “Biological effects of combined exposures to EMF and other chemical and physical agents” Erice, Italy, April 2014.
  • L. M. Mir (invited speaker): "Overview of therapeutical applications of combined exposures" at International School of Bioelectromagnetism « Alessandro Chiabrera » 7th Course “Biological effects of combined exposures to EMF and other chemical and physical agents” Erice, Italy, April 2014.
  • Talks in International Conferences

  • L. M. Mir, C. Y. Calvet and F. M. André: "Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cells" BIOELECTRICS 2014 - International Bioelectrics Symposium, Columbus, MI, USA, October 2014.
  • L. M. Mir: "Antitumor electrochemotherapy and irreversible electroporation: the different roles of cell electroporation" at MBEC2014 6th European Conference of the International Federation for Medical and Biological Engineering, Dubrovnik, Croatia, September 2014.
  • A. Azan, M. Scherman, B. Attal-Trétout, M. Breton, I. Leray and L. M. Mir: "Biochemical Characterization of Electropermeabilization using the Raman Effect" at URSI Scientific Symposium and General Assembly, Beijing, China, August 2014.
  • L. M. Mir, C. Y. Calvet and F. M. André:"Therapeutic Effects of in vivo Electroporation: Facilitating Drug and Gene Delivery but not Only" at URSI Scientific Symposium and General Assembly, Beijing, China, August 2014.
  • C. Poignard: "Free-boundary problem in cancer modeling" at Annual meeting of the Society of Math. Biology, Osaka, August 2014.
  • L. M. Mir, C. Y. Calvet and F. M. André: "In vivo electroporation: therapeutic effects are not just the consequence of a facilitated drug and gene delivery" at BioEM2014, Cape Town, South Africa, June 2014.
  • M. Breton, F. Salomone, L. Delemotte, I. Leray, F. Cardarelli, C. Boccardi, D. Bonhenry, M. Tarek, L. M. Mir and F. Beltram: "Molecular Mechanisms of Gene Electrotransfer induced by Nanopulses" at BioEM2014, Cape Town, South Africa, June 2014.
  • C. Poignard, M. Leguèbe, L.M Mir, A. Silve: "Conducting and permeable states of cell membrane submitted to high voltage pulses." at
  • Bioelectrics symposium in Sept 2013 (Karlsruhe, Germany)
  • M. Leguèbe, L. M. Mir, C. Poignard,A. Silve: "Modeling both conducting and permeable states of cell membrane submitted to high voltage pulses" at BioEM 2013 in June 2013 (Thessaloniki, Greece)
  • L.M. Mir: "Electroporation and electropermeabilization" at GRC on bioelectrochemistry in July 2012 (Lucca, Italy) and Bioelectrics symposiumSept 2012, Kumamoto, Japan)
  • A. Silve, I. Leray, M. Leguèbe, C. Poignard, L.M. Mir : "Extracellular conductivity: A powerful tool to investigate the mechanism of electropermeabilisation" at Bioelectrics symposium in Sept 2012 (Kumamoto, Japan)
  • C. Poignard, O. Kavian, M. Leguèbe, L.M. Mir, A. Silve, L. Weynans : "Numerical study of the influence of the medium conductivity through a new dynamic model of electropermeabilization" at Bioelectrics symposium in Sept 2012 (Kumamoto, Japan)
  • Posters in international conferences

  • M. Leguèbe, A. Silve, L. M. Mir and C. Poignard: "Cell Scale Electropermeabilization Modeling" at Gordon Research Conference on Bioelectrochemistry, Cellular and Organismal Responses to Endogenous and Exogenous Fields. University of New England Biddeford, MN, USA. July 6-11, 2014.
  • A. Azan, M. Scherman, B. Attal-Trétout, M. Breton, I. Leray and L. M. Mir: "Biochemical Characterization of Cell Electropermeabilization using the Raman Effect" at Gordon Research Conference on Bioelectrochemistry, Cellular and Organismal Responses to Endogenous and Exogenous Fields. University of New England Biddeford, USA, July 2014.
  • C. Y. Calvet, D. Famin, F. M. André and L. M. Mir: "Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cell line" at Gordon Research Conference on Bioelectrochemistry, Cellular and Organismal Responses to Endogenous and Exogenous Fields. University of New England Biddeford, USA, July 2014.
  • M. Leguèbe, A. Silve, L. M. Mir and C. Poignard: "Cell Scale Electropermeabilization Modeling" at Gordon Research Conference on Bioelectrochemistry, Cellular and Organismal Responses to Endogenous and Exogenous Fields. University of New England Biddeford, USA, July 2014.
  • L. L. Lesueur, L. M. Mir, T. Ragot, F. M. André: "In vitro electrotransfer of large plasmids" at American Society of Gene & Cell Therapy 17th Annual Meeting, Washington, DC, May 21-24, 2014.
  • C. Y. Calvet, J. Thalmensi, E. Pliquet, C. Liard, T. Bestetti, P. Langlade Demoyen, T. Huet and L. M. Mir: "Optimization of intradermal gene electrotransfer procedure for human telomerase-based DNA vaccination" at American Society of Gene & Cell Therapy 17th Annual Meeting, Washington, DC, USA, May 2014.
  • M. Leguèbe, A. Silve, L. Mir, C. Poignard: "Electropermeabilization at the cell scale" at Congrès CANUM at Carry-LeRouet, France, April 2014.
  • C. Poignard, A. Silve, L. Wegner: "Pore formation modeling in a membrane submitted to a high voltage pulse. The influence of membrane viscosity?" at the Annual Biophysical Meeting in February 2014 (San Francisco, USA).
  • M. Leguèbe, A. Silve, L.M. Mir, C. Poignard: "Electropermeabilization at the cell scale" at GRC on bioelectrochemistry in July 2012 (Lucca, Italy).
  • M. Breton, L. Delemotte, A. Silve, L.M. Mir, M. Tarek: "Transport of siRNA molecules through lipid membranes driven by nanosecond electric pulses: an experimental and computational study" at GRC on bioelectrochemistry in July 2012 (Lucca, Italy).
  • A. Silve, I. Leray, M. Leguèbe, C. Poignard, L.M. Mir : "Impact of external conductivity on permeabilisation by nanosecond pulses" at GRC on bioelectrochemistry in July 2012 (Lucca, Italy).

    Popular Science Talks

  • C. Poignard: "Des décharges électriques contre le cancer". 3 Talks given at "Unithé ou Café" (Jan. 2013, Inria Bordeaux), "Conférence C.P.G.E. du Lycée Montaigne"(Dec. 2013, Bordeaux), "Journées IREM"(May 2014, Bordeaux).

  • News and Events

  • 15th-16th Dec 2014:
    Workshop on electroporation and Biophysical therapies
  • 2nd-3rd Sept 2014:
    Meeting at Villejuif
  • 6th March 2014:
    Meeting at Lyon
  • 7-8th October 2013:
    Meeting at Paris (CR)
  • 19-20th february 2013:
    Meeting at Bordeaux (CR)
  • 14-15th November 2012:
    Meeting at Lyon (CR)
  • 13th March 2012:
    Meeting at Paris (CR)
  • January 2012:
    Kick-off meeting at Bordeaux
  • Links

  • ARC C3MB (2009-2010)
  • ANR INTCELL (2011-2013)


  • Project Coordinator

    Clair POIGNARD (website)
    EPI MC2
    INRIA Bordeaux-Sud Ouest
    351 Cours de la Libération
    F-33405 Talence, France
    webmaster